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(Preprint), Electronic health record phenotypes associated with genetically regulated expression of CFTR and application to cystic fibrosis, Temporal trend in the use of hysteroscopic vs laparoscopic sterilization and the characteristics of commercially insured and Medicaid-insured females in the US who have had the procedures, Effect of Laparoscopic Surgery on Health Care Utilization and Costs in Patients Who Undergo Colectomy, Burden of Gastrointestinal Disease in the United States: 2012 Update, Clinical and economic impact of infusion reactions in patients with colorectal cancer treated with cetuximab, Medical and Surgical Treatment of Parathyroid Diseases: An Evidence-Based Approach, Association of Preoperative Anti–Tumor Necrosis Factor Therapy With Adverse Postoperative Outcomes in Patients Undergoing Abdominal Surgery for Ulcerative Colitis, A comparison of patient-centered economic and clinical outcomes of post-mastectomy breast reconstruction between obese and non-obese patients, Costs of HPB surgery and readmissions in privately-insured US patients, Metformin for Primary Colorectal Cancer Prevention in Patients With Diabetes: A Case-Control Study in a US Population, Age differences in presentation, diagnosis pathway and management of colorectal cancer, Completeness of prescription information in US commercial claims databases, A claims-based Markov model for Crohn's disease. Patients with acute gout were infrequently seen by rheumatologists, whereas rheumatologist care progressively increased in patients with advanced gout. A Markov model was developed using administrative claims data for patients aged > or = 18 years with > or = 3 years of continuous enrolment from 2000 to 2008 and > or =2 Crohn's disease claims. Outline • MarketScan ® Commercial Claims and Encounters - nuts and bolts • Examples of use • Next steps. Measurement of serum urate and prescriptions for ULTs are not consistent in gout patients. Gout patients were seen most frequently by internists and family medicine practitioners. As shown in Table 2, the majority of pregnant women in the claims analysis were aged 30 to 39 (59.3% of the sumatriptan‐exposed cohort, 62.2% of the naratriptan‐exposed cohort, and 63.9% of the sumatriptan/naproxen sodium). Unlike preoperative anti-TNF agent use among patients who underwent colectomy or total proctocolectomy and experienced no significant increase in postoperative complications, anti-TNF agent use within 90 days of surgery among patients who underwent ileal pouch-anal anastomosis was associated with higher 90-day postoperative complication rates. General symptoms were more frequent in the eldest and abdominal symptoms in the youngest. We estimate the burden of GI disease in the United States. Methods: Data between 1 January 2006 and 31 December 2014 from patients aged 6-17 years in the Truven Health Analytics MarketScan database were used to generate two cohorts of patients: (1) atomoxetine users and (2) stimulant (methylphenidates or amphetamines) users. Gastroesophageal reflux was the most common GI diagnosis (8.9 million visits). Each cross section was treated independently to identify patients with at least two outpatient diagnoses of atrial fibrillation, two international normalized ratio tests, and one pharmacy claim. Overall, health care costs for patients with Crohn's disease increased with disease severity. To evaluate health care costs and costs per quality-adjusted life year (QALY) for Crohn's disease. For pregnancies exposed to sumatriptan during the second or third trimester, the proportion of major birth defects among linked infants was 3.9% in the claims analysis and 3.1% in the registry. This research may find broad applications for phenomic studies of Mendelian disease genes. Because environmental factors such as Western diet and obesity are implicated in the causation of CRC, a large case-control study was performed to assess the effects of metformin on the incidence of CRC in a US population.METHODS There are several limitations to this database, primarily related to the fact that individuals or their family members within two of the core databases mandatorily possess some form of employer-based health insurance, which prevents the dataset from being nationally representative. Background: This study evaluated the real-world practice patterns in gout patients using large administrative claims databases. IBM MarketScan Research Databases at UCSF (formerly Truven Health Analytics Inc.) Data Description . About 5120 pregnancies were identified in the retrospective claims cohort in contrast to 617 included in the prospective registry during the same time frame. The authors wish to acknowledge the contributions of the following colleagues from Amgen Inc.: Michael Gruber and Sarah Marshall for their assistance with the study analysis. 2015, Health Research Data for the Real World: The MarketScan Databases, Quint J. The overall prevalence of hypertension was significantly higher in the CEMR (33.5%) than in the NHANES (95% CI: 27.0%-31.0%). BACKGROUND The IBM® MarketScan® Research Databases are one of the largest proprietary collections of de-identified US patient data available for healthcare research. Pharmacy commercial claims databases are widely used for pharmacoepidemiologic research. Around 75% of migraine patients are women, and the prevalence of migraine is the highest for ages 20 to 50 years, when women are of reproductive age.7 Pharmacologic treatment of migraine during pregnancy is typically focused on acute medications, and sporadic use of triptans after the first trimester may be considered. Hence, individuals included in the database are covered under private insurance plans; no Medicaid or … Outcomes were evaluated by drug class and route of administration. Additionally, ROTO counts can inform HTN complications’ risk/management thereof. It presents a comprehensive treatment of parathyroid diseases as well as hundreds of high quality images and illustrations. Main Outcomes and Measures The Cochran-Armitage test was used to evaluate the utilization pattern of breast reconstruction surgery. All rights reserved. Understanding these strengths and limitations will help clinicians become more informed readers of the published literature. There is a need for alternative and or complementary methodological approaches to evaluating the safety of medications during pregnancy. Co-morbidities/persistence of ≥3 rounds of treatment options over 2 years further increased these odds and total medications/chronic disease score correlated with ROTO counts. Obesity was associated with higher odds of infectious, wound, and perfusion complications after TE/implant-based reconstruction, and higher odds of perfusion complications after autologous reconstruction. Professional Phd Phd Essay Sample; #AskMayor; News; Officials; Department Heads; Gallery; Tourism. Data were obtained from the Truven Health Analytics MarketScan Commercial Claims and Encounters database. Any queries (other than missing content) should be directed to the corresponding author for the article. This study evaluated the temporal trend in the use of hysteroscopic sterilization (HS) vs laparoscopic sterilization (LS) and characteristics of commercially insured and Medicaid-insured women in the US who have had the procedures. Only data regarding the first or index surgical admission within the time frame were abstracted. Data were collected and analyzed from February 1, 2015, to June 2, 2016. We observed a high resection rate independently of age but less adjuvant chemotherapy in Stage III colon cancer, and of radiotherapy in stage II and III rectal cancer as age increases. In conclusion, the findings of this study show that a sizable cohort of pregnant women exposed to medications of interest can be assembled using existing electronic health care databases. However, challenges to effective implementation of pregnancy exposure registries including difficulties in recruiting exposed patients, lack of adequate power to assess specific birth defects, and lack of adequate internal comparators have resulted in such registries failing to deliver robust information after many years of resource‐intensive engagement.3, 4, Not surprisingly, there is a need for complementary and alternative methods of assessing medication exposure in pregnancy, particularly observational studies using existing electronic administrative health care databases.4, 5 With the expansion and evolution of health and medical records systems over the past 2 decades, it may now be possible for well‐designed, pregnancy safety studies using existing databases to provide timely and high‐quality data. A. Yusuf, PhD, Center for Observational Research, Amgen Inc. 1 Amgen Center Drive, Thousand Oaks, CA 91320, USA. In addition, the prescription database lacks information on medication dispensed during hospital admissions or obtained from the doctor's office as samples. Truven Health offers healthcare data management, analytics, services and consulting to customers across the healthcare industry including hospitals & health systems, employers, health plans, life sciences companies, and state & federal government agencies. Possible reasons for patients not receiving 2 L treatment include still being on 1 L treatment, no requirement for 2 L treatment, refusal of treatment and death, although these cannot be reliably obtained from the claims database The majority of exposed pregnancies had triptan dispensed in the first trimester. Truven Health Analytics MarketScan ® Jodi Segal, MD, MPH. In contrast, in the US Truven MarketScan database, all events were captured using administrative codes, limiting clinical detail. The frequency of major birth defects among pregnancies with first‐trimester exposure to sumatriptan was 4.0% in both the claims analysis and the registry. The MarketScan databases are a family of administrative claims databases that contain data on inpatient and outpatient claims, outpatient prescription claims, clinical utilization records, and healthcare expenditures. Eleven supplemental databases are available, which are utilized to overcome the limited clinical data available in the core MarketScan databases. These claims-based data can be sourced from public insurers (eg, Medicare), private insurers (eg, United Health) or a mix of the two (eg, MarketScan). The Truven Health MarketScan Commercial Claims and Encounter Database and the Medicare Supplemental and Coordination of Benefits Database (Truven Health Analytics Inc, Ann Arbor, MI) included data from January 1, 2007, to September 30, 2015. Although the probabilities of transitioning from other health states to the severe-fulminant disease state were low, the cost/QALY was high. Purpose: Our study supports the possibility that some prescriptions may not be captured in US commercial insurance databases. Statistical analyses of the most recent data are necessary to guide GI research, education, and clinical practice. Data Source . The distribution of major cardiometabolic diseases in the NHANES, designed to assess the health and nutritional status of adults and children in the United States, was compared with similar data from the CEMR. Filled prescriptions of sumatriptan, naratriptan, and sumatriptan/naproxen sodium during the pregnancy episode were identified by National Drug Codes using pharmacy dispensing claims. Truven Health Analytics MarketScan Databases for Clinical Research in Colon and Rectal Surgery Clin Colon Rectal Surg . The pregnancy cohort is based on data from 2003 to 2014. A.Y., V.C., F.X., D.M., L.B., and C.C. Stage was similar by age group. Objective: To study the trends on JMG using Truven Health MarketScan commercial claims database. If features more than 264 million covered individuals, 37 billion service records, more than 160 contributing employers … In oncology, the term "big data" broadly describes the rapid acquisition and generation of massive amounts of information, typically from population cancer registries, electronic health records, or large-scale genetic sequencing studies. Acute pancreatitis was the most common reason for hospitalization (274,119 discharges). Background: There are limited published studies on JMG on incidence, prevalence, morbidity, mortality, investigations and therapeutic strategies in using insurance claims database. Results: The Truven Medicare database contains the healthcare experience of individuals with Medicare supplemental insurance paid for by employers. The proportion of major birth defects among first‐semester sumatriptan exposures was 4.0%, which is exactly the same as the proportion of major birth defects reported for first‐semester sumatriptan exposures in the registry. Out of 111 170 patients, the percentage of patients with any warfarin drug decreased slightly from 91.7% (95% CI: 91.0, 92.4) in early 2003 to 87.1% (95% CI: 86.7-87.6) in late 2009 (χ(2) = 93.8, p < 0.0001). Methods: We selected members who had complete enrollment in 2012 from the Truven MarketScan Commercial Claims and Encounters (CCAE) and the Optum Clinformatics (Optum) databases. Methods: PheRS constructed using the EHR phenotypes and weights discovered by the genetic associations improved discriminative power for CF over the initially proposed PheRS in both VUMC and MarketScan. Background: The top associated EHR phenotypes were assessed in combination as a phenotype risk score (PheRS) for discriminating CF case status in an additional 2.8 million patients from Vanderbilt University Medical Center (VUMC) and 125,305 adult patients including 25,314 CF cases from MarketScan, an independent external cohort. MarketScan data also contain diagnoses which can be used to determine the influence of clinical, demographic, and provider characteristics upon prescribing patterns. AU - Kulaylat, Audrey S. AU - Schaefer, Eric W. AU - Messaris, Evangelos. About 4519 pregnancies were exposed to sumatriptan, 230 were exposed to naratriptan, and 371 were exposed to sumatriptan/naproxen sodium. Database Name: MarketScan® Commercial Claims and Encounters and Medicare Supplemental and Coordination of Benefits. In primary care, only ultrasound is more frequently ordered in those <65 years. Design/Methods: We interrogated Truven Health MarketScan commercial claims and encounter databases for JMG for … A total of 1122 CRC patients receiving cetuximab were identified. The MarketScan® Commercial Claims and Encounters Data (CCAE) is produced by IBM Watson Health. Emerging evidence from observational studies has suggested that metformin may be beneficial in the primary prevention of colorectal cancer (CRC). Marketscan® File Structure. The authors state that no ethical approval was needed. are employees and stockholders of Amgen Inc. No Amgen products were evaluated in this study. T1 - Truven Health Analytics MarketScan Databases for Clinical Research in Colon and Rectal Surgery. In summary, endophenotype‐based network medicine methodologies will promote AD therapeutic development that will optimize the usefulness of available data and support deep phenotyping of the patient heterogeneity for personalized medicine in AD. The generation of mother‐infant pairs is dependent on the infant being covered under the same insurer as the mother, and mother‐infant linkage algorithm used in this study linked 75.3% of live‐born infants to their mothers. The Truven Database was queried for subjects that underwent meniscus allograft transplantation (Current Procedural Terminology code 29868) in the outpatient setting with minimal 2-year follow-up. Among both commercially insured and Medicaid-insured women, the likelihood of having HS vs LS increased over time. Physician-graded toxicity is a relatively more objective measure, but relies on both clinicians fully assessing all relevant symptoms and patients accurately reporting them to the clinician. The MarketScan Medicare Supplemental and Coordination of Benefits Database is a research database owned by Truven Health Analytics. In the United States, the Food and Drug Administration requires industry sponsors to conduct these pregnancy safety studies as part of postmarketing commitments or postmarketing requirements. Study approaches and methods to evaluate the safety of drugs and biological products during pregnancy in the post‐approval setting; public meeting; request for comments, Underreporting of induced and spontaneous abortion in the United States: an analysis of the 2002 National Survey of Family Growth, Enrollment and retention in 34 United States pregnancy registries contrasted with the manufacturer's capture of spontaneous reports for exposed pregnancies. Marketscan Commercial Claims and Encounters and Medicare Supplemental Databases; … A Cox proportional hazards regression model was used to compare incidence of dystonia across propensity score … This article provides an overview of how big data approaches can be applied in cancer research, and how they can be used to translate information into new ways to ultimately make informed decisions that improve cancer care and delivery. New HTN patients with ≥2 rounds of treatment options (vs single/initial round) were associated with ∼5-fold or higher predicted HTN complications’ risk (p-value < 0.0001). Retrospective multivariate regression analysis of national health insurance claims data was used to evaluate health care utilization and costs up to 1 year following elective colectomy. ... 16,17 Other examples of health maintenance organization and private-sector databases include the Kaiser Permanente Clinical Research Networks and MarketScan by Truven Health. These databases include healthcare claims for outpatient services from all levels of care, outpatient … Metformin exposure was assessed by prescription tracking within the 12-month period before the index date. Home; Professional Argumentative Essay Writer Services Usa. Gestation age for deliveries without an ICD‐9‐CM diagnosis code for preterm or postterm birth was assumed to be 273 days. Consecutive incident cases of CRC were identified from pathology services. States: 2014. IBM MarketScan Research Databases. It reflects the healthcare of retirees with Medicare supplemental insurance paid by employers. Methods: Utilizing the Truven Marketscan ® research database, 554,806 patients who underwent cholecystectomy in calendar years 2011-2014 were identified using ICD-9 procedure and diagnosis codes. Cost also increases for each case which can be used to evaluate the effect of laparoscopic vs open on... 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